Grey matter atrophy in cognitively impaired Parkinson's disease
Identifieur interne : 000041 ( Main/Exploration ); précédent : 000040; suivant : 000042Grey matter atrophy in cognitively impaired Parkinson's disease
Auteurs : Tracy R. Melzer [Nouvelle-Zélande] ; Richard Watts [Nouvelle-Zélande] ; Michael R. Macaskill [Nouvelle-Zélande] ; Toni L. Pitcher [Nouvelle-Zélande] ; Leslie Livingston [Nouvelle-Zélande] ; Ross J. Keenan [Nouvelle-Zélande] ; John C. Dalrymple-Alford [Nouvelle-Zélande] ; Tim J. Anderson [Nouvelle-Zélande]Source :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2012-02.
Abstract
Objective Mild cognitive impairment and dementia are common non-motor features of Parkinson's disease (PD). The aim of this study was to characterise grey matter changes associated with clearly defined stages of cognitive impairment in PD using structural MRI. Methods 96 PD subjects were classified using detailed cognitive testing as PD with normal cognition (PD-N, n=57), PD with mild cognitive impairment (PD-MCI, n=23) or PD with dementia (PD-D, n=16); 34 controls matched for mean age and sex ratio also participated. Grey matter volume differences were evaluated using voxel based morphometry of grey matter segments derived from T1 weighted 3 T MRI, and multiple linear regression assessed the relationship between cognitive and motor impairments and grey matter concentration. Results Compared with controls, no grey matter differences were found in PD-N. PD-MCI showed limited grey matter atrophy in the temporal, parietal and frontal cortex as well as the bilateral caudal hippocampus, amygdala and right putamen. PD-D subjects exhibited far more extensive atrophy in regions involved in PD-MCI but also had reduced grey matter volume in other large areas of the temporal lobe (including the parahippocampi), the intracalcarine and lingual gyri, posterior cingulate gyrus, frontal regions and bilateral caudate. Grey matter loss in PD correlated with global cognitive score but not motor impairment in most of these regions. Interpretation Marked grey matter atrophy occurs in PD with dementia but far less extensive changes are evident in PD-MCI. Some grey matter atrophy precedes the development of dementia but may be accelerated once frank dementia begins.
Url:
DOI: 10.1136/jnnp-2011-300828
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Grey matter atrophy in cognitively impaired Parkinson's disease</title><author><name sortKey="Melzer, Tracy R" sort="Melzer, Tracy R" uniqKey="Melzer T" first="Tracy R" last="Melzer">Tracy R. Melzer</name></author><author><name sortKey="Watts, Richard" sort="Watts, Richard" uniqKey="Watts R" first="Richard" last="Watts">Richard Watts</name></author><author><name sortKey="Macaskill, Michael R" sort="Macaskill, Michael R" uniqKey="Macaskill M" first="Michael R" last="Macaskill">Michael R. Macaskill</name></author><author><name sortKey="Pitcher, Toni L" sort="Pitcher, Toni L" uniqKey="Pitcher T" first="Toni L" last="Pitcher">Toni L. Pitcher</name></author><author><name sortKey="Livingston, Leslie" sort="Livingston, Leslie" uniqKey="Livingston L" first="Leslie" last="Livingston">Leslie Livingston</name></author><author><name sortKey="Keenan, Ross J" sort="Keenan, Ross J" uniqKey="Keenan R" first="Ross J" last="Keenan">Ross J. Keenan</name></author><author><name sortKey="Dalrymple Alford, John C" sort="Dalrymple Alford, John C" uniqKey="Dalrymple Alford J" first="John C" last="Dalrymple-Alford">John C. Dalrymple-Alford</name></author><author><name sortKey="Anderson, Tim J" sort="Anderson, Tim J" uniqKey="Anderson T" first="Tim J" last="Anderson">Tim J. Anderson</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:2B0716691624F7E3B8AC0A4CB501FEF59C75618A</idno><date when="2012" year="2012">2012</date><idno type="doi">10.1136/jnnp-2011-300828</idno><idno type="url">https://api.istex.fr/document/2B0716691624F7E3B8AC0A4CB501FEF59C75618A/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001024</idno><idno type="wicri:Area/Main/Curation">000E36</idno><idno type="wicri:Area/Main/Exploration">000041</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Grey matter atrophy in cognitively impaired Parkinson's disease</title><author><name sortKey="Melzer, Tracy R" sort="Melzer, Tracy R" uniqKey="Melzer T" first="Tracy R" last="Melzer">Tracy R. Melzer</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Van der Veer Institute for Parkinson's and Brain Research, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Medicine, University of Otago, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Nouvelle-Zélande</country></affiliation></author><author><name sortKey="Watts, Richard" sort="Watts, Richard" uniqKey="Watts R" first="Richard" last="Watts">Richard Watts</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Van der Veer Institute for Parkinson's and Brain Research, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Physics and Astronomy, University of Canterbury, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Macaskill, Michael R" sort="Macaskill, Michael R" uniqKey="Macaskill M" first="Michael R" last="Macaskill">Michael R. Macaskill</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Van der Veer Institute for Parkinson's and Brain Research, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Medicine, University of Otago, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Pitcher, Toni L" sort="Pitcher, Toni L" uniqKey="Pitcher T" first="Toni L" last="Pitcher">Toni L. Pitcher</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Van der Veer Institute for Parkinson's and Brain Research, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Medicine, University of Otago, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Livingston, Leslie" sort="Livingston, Leslie" uniqKey="Livingston L" first="Leslie" last="Livingston">Leslie Livingston</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Van der Veer Institute for Parkinson's and Brain Research, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Medicine, University of Otago, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Keenan, Ross J" sort="Keenan, Ross J" uniqKey="Keenan R" first="Ross J" last="Keenan">Ross J. Keenan</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Christchurch Radiology Group, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Dalrymple Alford, John C" sort="Dalrymple Alford, John C" uniqKey="Dalrymple Alford J" first="John C" last="Dalrymple-Alford">John C. Dalrymple-Alford</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Van der Veer Institute for Parkinson's and Brain Research, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Medicine, University of Otago, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Psychology, University of Canterbury</wicri:regionArea><wicri:noRegion>University of Canterbury</wicri:noRegion></affiliation></author><author><name sortKey="Anderson, Tim J" sort="Anderson, Tim J" uniqKey="Anderson T" first="Tim J" last="Anderson">Tim J. Anderson</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Van der Veer Institute for Parkinson's and Brain Research, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Medicine, University of Otago, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Neurology, Christchurch Hospital, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2012-02">2012-02</date><biblScope unit="volume">83</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="188">188</biblScope></imprint><idno type="ISSN">0022-3050</idno></series><idno type="istex">2B0716691624F7E3B8AC0A4CB501FEF59C75618A</idno><idno type="DOI">10.1136/jnnp-2011-300828</idno><idno type="href">jnnp-83-188.pdf</idno><idno type="ArticleID">jnnp-2011-300828</idno><idno type="PMID">21890574</idno><idno type="local">jnnp;83/2/188</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Objective Mild cognitive impairment and dementia are common non-motor features of Parkinson's disease (PD). The aim of this study was to characterise grey matter changes associated with clearly defined stages of cognitive impairment in PD using structural MRI. Methods 96 PD subjects were classified using detailed cognitive testing as PD with normal cognition (PD-N, n=57), PD with mild cognitive impairment (PD-MCI, n=23) or PD with dementia (PD-D, n=16); 34 controls matched for mean age and sex ratio also participated. Grey matter volume differences were evaluated using voxel based morphometry of grey matter segments derived from T1 weighted 3 T MRI, and multiple linear regression assessed the relationship between cognitive and motor impairments and grey matter concentration. Results Compared with controls, no grey matter differences were found in PD-N. PD-MCI showed limited grey matter atrophy in the temporal, parietal and frontal cortex as well as the bilateral caudal hippocampus, amygdala and right putamen. PD-D subjects exhibited far more extensive atrophy in regions involved in PD-MCI but also had reduced grey matter volume in other large areas of the temporal lobe (including the parahippocampi), the intracalcarine and lingual gyri, posterior cingulate gyrus, frontal regions and bilateral caudate. Grey matter loss in PD correlated with global cognitive score but not motor impairment in most of these regions. Interpretation Marked grey matter atrophy occurs in PD with dementia but far less extensive changes are evident in PD-MCI. Some grey matter atrophy precedes the development of dementia but may be accelerated once frank dementia begins.</div></front></TEI><affiliations><list><country><li>Nouvelle-Zélande</li></country></list><tree><country name="Nouvelle-Zélande"><noRegion><name sortKey="Melzer, Tracy R" sort="Melzer, Tracy R" uniqKey="Melzer T" first="Tracy R" last="Melzer">Tracy R. Melzer</name></noRegion><name sortKey="Anderson, Tim J" sort="Anderson, Tim J" uniqKey="Anderson T" first="Tim J" last="Anderson">Tim J. Anderson</name><name sortKey="Anderson, Tim J" sort="Anderson, Tim J" uniqKey="Anderson T" first="Tim J" last="Anderson">Tim J. Anderson</name><name sortKey="Anderson, Tim J" sort="Anderson, Tim J" uniqKey="Anderson T" first="Tim J" last="Anderson">Tim J. Anderson</name><name sortKey="Dalrymple Alford, John C" sort="Dalrymple Alford, John C" uniqKey="Dalrymple Alford J" first="John C" last="Dalrymple-Alford">John C. Dalrymple-Alford</name><name sortKey="Dalrymple Alford, John C" sort="Dalrymple Alford, John C" uniqKey="Dalrymple Alford J" first="John C" last="Dalrymple-Alford">John C. Dalrymple-Alford</name><name sortKey="Dalrymple Alford, John C" sort="Dalrymple Alford, John C" uniqKey="Dalrymple Alford J" first="John C" last="Dalrymple-Alford">John C. Dalrymple-Alford</name><name sortKey="Keenan, Ross J" sort="Keenan, Ross J" uniqKey="Keenan R" first="Ross J" last="Keenan">Ross J. Keenan</name><name sortKey="Livingston, Leslie" sort="Livingston, Leslie" uniqKey="Livingston L" first="Leslie" last="Livingston">Leslie Livingston</name><name sortKey="Livingston, Leslie" sort="Livingston, Leslie" uniqKey="Livingston L" first="Leslie" last="Livingston">Leslie Livingston</name><name sortKey="Macaskill, Michael R" sort="Macaskill, Michael R" uniqKey="Macaskill M" first="Michael R" last="Macaskill">Michael R. Macaskill</name><name sortKey="Macaskill, Michael R" sort="Macaskill, Michael R" uniqKey="Macaskill M" first="Michael R" last="Macaskill">Michael R. Macaskill</name><name sortKey="Melzer, Tracy R" sort="Melzer, Tracy R" uniqKey="Melzer T" first="Tracy R" last="Melzer">Tracy R. Melzer</name><name sortKey="Melzer, Tracy R" sort="Melzer, Tracy R" uniqKey="Melzer T" first="Tracy R" last="Melzer">Tracy R. Melzer</name><name sortKey="Pitcher, Toni L" sort="Pitcher, Toni L" uniqKey="Pitcher T" first="Toni L" last="Pitcher">Toni L. Pitcher</name><name sortKey="Pitcher, Toni L" sort="Pitcher, Toni L" uniqKey="Pitcher T" first="Toni L" last="Pitcher">Toni L. Pitcher</name><name sortKey="Watts, Richard" sort="Watts, Richard" uniqKey="Watts R" first="Richard" last="Watts">Richard Watts</name><name sortKey="Watts, Richard" sort="Watts, Richard" uniqKey="Watts R" first="Richard" last="Watts">Richard Watts</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000041 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000041 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:2B0716691624F7E3B8AC0A4CB501FEF59C75618A
|texte= Grey matter atrophy in cognitively impaired Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |